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Although unnoticed in earlier studies, mice homozygous for the hypomorphic Egfr allele 'waved-2' (wa2) exhibited semilunar valve enlargement resulting from overabundant mesenchymal cells.

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Instead, phospho-ERK in the gefitinib-resistant cultures of HCC4006, HCC2279 and H1650 cells was reduced or abolished by the FGFR1-specific TKI, AZ8010, and the FGFR-active TKI, RO4383596 ( and Supplementary Figure S4).

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